GAD Peptide Vaccines for T 1 DM : Not Just a Blueprint ?
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چکیده
منابع مشابه
Editing of an immunodominant epitope of glutamate decarboxylase by HLA-DM.
HLA-DM stabilizes peptide-receptive class II alphabeta dimers and facilitates the capture of high affinity peptides, thus influencing the peptide repertoire presented by class II molecules. Variations in DM levels may therefore have a profound effect on the antigenic focus of T cell-mediated immune responses. Specifically, DM expression may influence susceptibility and resistance to autoimmune ...
متن کاملActivation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus
BACKGROUND The origin of autoimmune disease type 1 diabetes is still unknown. AIM This study assessed the activation of CD4+ and CD8+ T-lymphocytes by human insulin and human glutamate decarboxylase (GAD) in patients with type 1 or type 2 diabetes mellitus (DM) and healthy volunteers. MATERIALS AND METHODS The expression of CD69, a marker of T-lymphocyte activity, was determined in whole bl...
متن کاملAnti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus.
The aim of our study was to evaluate antibodies against thyroglobulin (anti-TG) and thyroid peroxidase (anti-TPO) - markers of autoimmune thyroiditis - in several groups of adult patients with type 1 and type 2 diabetes mellitus (DM). We were particularly interested whether the presence of thyroid antibodies is related to the positivity of glutamic acid decarboxylase antibodies (anti-GAD). We f...
متن کاملاثربخشی روان درمانگری تحلیل ارتباط متقابل بر کاهش نشانه‌های اختلال اضطراب تعمیم‌یافته
Background & Aims : Generalized anxiety disorder (GAD) is a common psychiatric disorder. Although it seems that psychotherapy transaction analysis has a significant role in reducing the symptoms of anxiety, but studies about the effectiveness of these interventions on the GAD symptoms are not frequent. This study was aimed to study the efficacy of psychotherapy transactional analysis on dec...
متن کاملDetection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers.
CD4(+) T cells selected by the type 1 diabetes associated class II MHC I-A(g7) molecules play a critical role in the disease process. Multivalent MHC/peptide tetramers have been used to directly detect antigen-specific T cells. Detection of autoantigen-activated CD4(+) T cells with tetramers should be very helpful in the study of the roles of these cells in diabetes. We report here the generati...
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تاریخ انتشار 2003